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placeholder http://covenantuniversity.edu.ng/Profiles/AJANI-OLAYINKA-OYEWALE
AJANI OLAYINKA OYEWALE

Contents

  1. College
  2. School
  3. Department
  4. Research Interests
  5. Awards & Honours
  6. Teaching Areas
  7. Current Postgraduate Supervision
  8. Selected Publications (40)
  9. Collaboration/Linkages
  10. Conferences Attended
  11. Summary of Profile
  12. Curriculum Vitae

Prof. OLAYINKA OYEWALE AJANI

Professor of Organic Chemistry

B.Sc (Ife), M.Sc (Ife), Ph.D (Covenant University), MICCON, MCSN, MACS

College

College of Science and Technology

School

Departments

Department

Chemistry

Research Interests

Organic Synthesis and Medicinal Chemistry

  • Over ten years of research experience in organic synthesis and medicinal chemistry.
  • Successfully designed and synthesized bioactive quinoxaline derivatives using microwave irradiation technique as a green approach.
  • Successfully synthesized potential ligands and metal complexes with promising antimicrobial versatilities.
  • Expertise in chromatographic purification, spectral characterization, process research and scale-up operations.
  • Experience in derived and utilized structure activity relationships (SAR) to improve the efficacy of drug candidates.
  • Experienced in designing and executing multi-steps synthesis of various bio-active molecules.
  • Working knowledge of most of the chemical databases and software in structural elucidation.

Awards & Honours

(1) German DAAD Academic Exchange WAFIRA Conference Sponsorship (2016)

(2) German DAAD Fellowship for short Research Stay for Research Scientists (2015)

(3) Merit Award as the Most Outstanding Faculty in Final Year Lecture Delivery in Chemistry (2015).

(4) TWAS Research Grant Award to Individual Scientists in Basic Science. FR No: 14069RG/CHE/AF/AC_I (2015).

(5) Certificate of Recognition as Outstanding Elsevier Reviewer for European Journal of Medicinal Chemistry (2014).

(6) Certificate of Recognition as Top Cited Author in Bioorganic and Medicinal Chemistry Year 2010-2011, by Elsevier Publishing, Netherland (2012).

(7) Certificate of Recognition for Outstanding Research Achievement, Chinese Academy of Science, Beijing (2011).

(8) Cash Award for Publishing Scientific Research in Journal with High Impact Factor (2010).

(9) Award of 2009 CAS-TWAS Postgraduate Fellowship Award FR Number: 3240223239 (2009).

(10) Best Class Adviser, Department of Chemistry Covenant University 2012.

(11) Best Examination Officer, Department of Chemistry Covenant University (2009).

(12) Best Class Adviser, Department of Chemistry Covenant University 2008.

Teaching Areas

Organic Chemistry, theory and practical as well as General Chemistry at all levels of undergraduate study.

  1. CHM 121 – General Organic Chemistry
  2. CHM 129 – Experimental Chemistry II
  3. CHM 119 – Experimental Chemistry I
  4. CHM 221 – Basic Organic Chemistry
  5. CHM 228 – Experimental Organic Chemistry I
  6. CHM 312 – Organic Chemistry
  7. CHM 313 – Experimental Organic Chemistry II
  8. CHM 412 – Seminar
  9. CHM 418 – Natural Product Chemistry
  10. CHM 433 – Wood, Pulp and Paper Chemistry
  11. CHM 426 – Pulp and Paper Technology
  12. CHM 818 – Synthetic Organic Chemistry
  13. CHM 827 – Organic Reaction Mechanism
  14. CHM 884 – Paints and Adhesives
  15. CHM 911 - Advanced Applied Spectroscopy

Current Postgraduate Supervision

Organic Synthesis and Medicinal Chemistry

Selected Publications (40)

1. Room temperature phyto-synthesis of Ag/Co bimetallic nanoparticles using aqueous leaf extract of Canna indica

[ Download 1.75 MB ]

2. Modeling and synthesis of Ag and Ag/Ni allied bimetallic nanoparticles by green method: Optical and biological properties.

[ Download 4.84 MB ] [Visit]

3. Microwave assisted synthesis and antimicrobial potential of quinoline-based 4-hydrazide-hydrazone derivatives

[Visit]

4. Proximate composition, structural characterization and phytochemical screening of the seed oil of Adenanthera pavonina linn

[ Download 149.09 kB ] [Visit]

5. Facile synthesis, characterization and antimicrobial activity of 2-alkanamino benzimidazole derivatives

[ Download 446.80 kB ] [Visit]

6. Characterization, proximate composition and evaluation of antimicrobial activity of seed oil of Bauhinia tomentosa

[ Download 210.60 kB ] [Visit]

7. Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

[Visit]

8. Preliminary studies on the seed oil of Caryota mitis: Proximate composition, phytochemical screening and evaluation of antimicrobial activity

[ Download 316.76 kB ] [Visit]

9. Quinazoline pharmacophore in therapeutic medicine

[ Download 1.25 MB ] [Visit]

10. Effect of polyol on multiple ligand capped silver alloyed nanobimetallic particles in tri-n-octylphosphine oxide and oleic acid matrices

[ Download 3.17 MB ] [Visit]

11. Expeditious synthesis and spectroscopic characterization of 2-methyl-3-substituted-quinazolin-4(3H)-one derivatives

[ Download 540.99 kB ] [Visit]

12. Tandem synthesis of some low and high indexed monometallic nanoparticles in polyols, poly(vinylpyrrolidone), trisodium citrate and dodecanethiol matrices.

[ Download 1.82 MB ]

13. Exploration of the chemistry and biological properties of pyrimidine as a privileged pharmacophore in therapeutic

[ Download 396.80 kB ] [Visit]

14. Comparative Study of the Antibacterial Activity of N, N-Diethylamido Substituted p-Toluenesulfonamides to their α-Toluenesulfonamide Counterparts

[ Download 223.79 kB ] [Visit]

15. Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

[Visit]

16. Synthesis and antibacterial activity of N,N-diethylamide bearing benzene sulfonamide derivatives.

[ Download 1.04 MB ] [Visit]

17. Synthesis and Antibacterial Activity of N,N-Diethyl-3-substituted-2- (4-methyl-phenylsulfonamido)alkanamides and their Arylsulfonamide Precursors

[ Download 583.30 kB ] [Visit]

18. Synthesis and Spectroscopic Study of Naphtholic and Phenolic Azo Dyes

[ Download 1.20 MB ] [Visit]

19. Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study

[ Download 510.89 kB ] [Visit]

20. Identification and Clinical Relevance of Gram-Positive Spore Formers

[Visit]

21. Synthesis, characterization, antimicrobial activity and toxicology study of some metal complexes of mixed antibiotics

[ Download 133.43 kB ] [Visit]

22. Fe(III) and Co(II) complexes of mixed antibiotics: synthesis, characterization, antimicrobial potential and their effect on alkaline phosphatase activities of selected rat tissues

[ Download 122.52 kB ] [Visit]

23. Synthesis, physical properties, antimicrobial potentials of some mixed antibiotics complexed with transition metals and their effect on alkaline phosphatase activities of selected rat tissues

[ Download 172.19 kB ] [Visit]

24. Evaluation of antibacterial activity of Pisidium guajava and Gongronema latifolium

[ Download 71.93 kB ] [Visit]

25. Physical characterisation of some honey samples from North-Central Nigeria

[ Download 406.76 kB ] [Visit]

26. Antibacterial effects of extracts of Ocimum gratissimum and piper guineense on Escherichia coli and Staphylococcus aureus

[ Download 74.13 kB ] [Visit]

27. Comparative study of microwave assisted and conventional synthesis of novel 2- quinoxalinone-3-hydrazone derivatives and its spectroscopic properties

[ Download 159.39 kB ] [Visit]

28. Synthesis and evaluation of antimicrobial activity of phenyl and furan-2-yl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one and their hydrazone precursors

[ Download 4.96 MB ] [Visit]

29. Synthesis and antibacterial activity of some pyrazol-1-ylquinoxalin-2(1H)-one derivatives

[Visit]

30. Improvement of nutritive value of sorghum ogi fortified with Pawpaw (Carica papaya L.)

[ Download 111.88 kB ] [Visit]

31. Histological studies of brewery spent grains in dietary protein formulation in donryu rats

[ Download 5.07 MB ] [Visit]

32. Microwave assisted synthesis and evaluation of antimicrobial activity of 3-{3-(s-aryl and s-heteroaromatic) acryloyl}-2H-chromen-2-one derivatives

[Visit]

33. Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives

[Visit]

34. Adsorption behaviour of pyrazolo[3,4-b]pyridine on corrosion of stainless steel in HCl solutions

[ Download 484.50 kB ] [Visit]

35. Functionalized 1,4-benzothiazine: A versatile scaffold with diverse biological properties

[Visit]

36. Eco-friendly room temperature synthesis in aqueous medium: An expeditious approach to new α-tolylsulfonamides bearing N,N-diethyl amide moieties

[ Download 529.86 kB ] [Visit]

37. Towards the conversion of carbohydrate biomass feedstocks to biofuels via hydroxylmethylfurfural

[ Download 475.20 kB ] [Visit]

38. Facile synthesis and characterization of substituted pyrimidin-2(1H)-ones and their chalcone precursors.

[ Download 9.77 MB ] [Visit]

39. Room temperature synthesis and antibacterial activity of new sulfonamides containing N,N-diethyl-substituted amido moieties

[ Download 752.59 kB ] [Visit]

40. Facile Synthesis and Characterization of New 2,3-Disubstituted Benzimidazole Derivatives

[ Download 1.29 MB ] [Visit]

Collaboration/Linkages

(1) Antimalarial Drug Synthesis and Bioasssay with Professor Martin Schlitzer of Institute for Pharmaceutical Chemistry, Marburg University, Germany. http://www.pharmazie.uni-marburg.de/forschung/pharmchem/ak-schlitzer/mitarbeiter/personen/ajani

(2) Functionalized Bioactive Research Project with Professor Feipeng Wu of Technical Institute of Physics and Chemistry (Chinese Academy of Sciences), Beijing, China.

(3) Antimicrobial Compounds and Biomolecules Project with Professor Markus W. Germann of Department of Chemistry, Georgia State University, Natural Science Center, USA.

(4) Member, Precipitated Carbonate Research Cluster.

(5) Member, Metal silicates and Silicon Oil Research Clusters.

Conferences Attended

Ajani O.O., Tolu-Bolaji O.O., Zhao Y., Aderohunmu D.V. and Audu O.Y. (2017). Facile synthesis of N-substituted-2-(3,5dinitrophenyl) benzimidazole derivatives for antimicrobial investigation. Proceeding of 7th International Conference on Advances in Applied Science and Environmental Engineering. GTower Hotel, Kualar Lumpur Malaysia, 1st to 2nd of July, 2017.

Ajani, O.O., Germann M.W., Iyaye K.T., Bello B.L. and Olorunshola S.J. (2017). Microwave assisted synthesis of N’-(Alkanylidene)-2-propyl quinoline-4-carbohydrazide derivatives and their antimicrobial potential. Proceeding of 7th International Conference on Advances in Applied Science and Environmental Engineering. GTower Hotel, Kualar Lumpur Malaysia, 1st to 2nd of July, 2017.

Webinar Conference on “Dynamic Nuclear Polarization in the study of pharmaceuticals” on Wednesday 26th July, 2017 at Bruker BioSpin Corporation, Madison, USA.

Ajani O.O., Tolu-Bolaji O.O., Zhao Y. and Aderohunmu, D.V. (2017). Eco-friendly synthesis and spectral study of novel series of 2-substituted benzimidaz- ole derivatives. Oral presentation at the South-West Zonal Conference of the Chemical Society of Nigeria (CSN), Held at New Mass Communication Building of the MAPOLY, Ojere, Abeokuta on Thursday 18th of May to Saturday 20th of May, 2017.

Ajani O.O., Iyaye K.T., Olanrewaju I.O., Germann M.W., Babatunde L.B. and Olorunshola S.J. (2016). Microwave assisted synthesis and antimicrobial evaluation of N’-(substituted-benzylidene)-2-propyl quinoline-4-carbohydrazide derivatives. Presentation at the CSN International Conference tagged GARDEN CITY-2016, Held at RSUST, Port Harcourt on 18 – 23rd September, 2016.

Ajani O.O.*, Owoeye T.F., Olanrewaju I.O., Adedapo A.E. and Ajanaku C.O. (2015). Heterogeneous catalytic efficiency of silica sulfuric acid towards the synthesis of pyrimidin-2(1H)-one derivatives. International Conference of the Chemical Society of Nigeria tagged Abuja 2015 held at International Conference Centre Abuja on 7 – 11th September, 2015.

Lecture Presentation titled “Computer-Aided Active Site Analysis for Target Assessment” by Dr. Adrea Volkamer, on Monday 20th January 2014 at Institute of Pharmaceutical Chemistry, Philipps Universität, Hessen, Germany.

Conference on “Mobile infrared spectrometry on polymeric materials: Qualification, verification and counterfeit detection” held on Tuesday 24th of September, 2013 at The boulevard, Langford Lane, Kidlington, Oxford OX5, 1GB. Elsevier in association with Agilent Technologies.

Workshop on the High Performance Computing with marc2 held at University Computer Centre (Lahnberge), Hans-Meer-Wein Strasse, Marburg, Germany on Wednesday 19th of June, 2013.

Global Bioprocessing Webinar on Leveraging Sample Bioprocessing Strategies in Translational Medicine to Advance Product Discovery and Development, Held at BioStorage Technologies, Indianapolis, USA on 25th of April, 2013.

Leadership and Corporate Performance 2011: A Leadership Business Breakfast Meeting. Held at Covenant University Guest House on Tuesday 20th of December, 2011.

2010 TWAS Frontier in Water and Sanitation: A Workshop for Water Engineers and Scientists from Developing Countries. Held in Beijing from 16th to 21st of August, 2010.

Obafemi, C.A., Oyenekan, M.B., Ajani, O.O. (2004). Microwave Assisted Approach to Environment-friendly Synthesis of Organic Compounds. Nigeria Society of Environmental Management Conference Paper. Held in OAU, Ile-ife, Osun State November 2004.

Summary of Profile

Prof. Olayinka Oyewale AJANI is an expeditious chemist who has distinguished himself both as a seasoned industrialist and a prolific researcher in the academic world especially in the area of Organic Synthesis and Medicinal Chemistry. He obtained his Master’s degree in Chemistry in 2006 from Obafemi Awolowo University, Ile-ife, Osun State, Nigeria. In 2012, Ajani O.O. obtained his Doctoral degree in Chemistry from Covenant University, Ota, Ogun State, Nigeria with research focus on synthesis of functionalized and biologically active sulphonamide scaffolds. Prof. Ajani is a recipient of various outstanding awards and recognition such as 2009 CAS-TWAS PG Fellowship Award. He has also distinguished himself as a prolific author by earning a certificate of recognition as a top cited author in 2010-2011 from Elsevier Publisher (Bioorganic and Medicinal Chemistry). He has been actively involved in research through self-initiation and collaboration with other researchers and this has been leading to publications in accredited/peer-reviewed scientific journals.
Prof. Ajani has a strong background in synthetic organic chemistry where he is engaged in: synthetic modification of polyfunctionalized molecules, designing of highly expeditious pathway towards preparation of various bioactive nitrogen and sulphur containing heterocyclic compounds, utilization of various cross coupling strategies to achieve targeted novel sulphonamides as scaffolds of high pharmacological relevance, engaging cutting-edge approach for purification of novel synthesized compounds, expertise in small molecule drug discovery and development process via microwave assisted organic synthetic (MAOS) approach.

Curriculum Vitae

Curriculum Vitae_AJANI O.O._14.08.2020.pdf 406.68 kB
 
 
Last Updated:

09/05/2020 05:47 pm

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