Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico
Plasmodium falciparum causes the most severe malaria pathogen and has developed resistance to existing drugs making it indispensable to discover new drugs. In order to predict drug targets in silico, a useful model for the metabolism is needed. However, automatically reconstructed network models typically cover more non-confirmed enzymes than confirmed enzymes of known gene products....
Fatumo S, Plaimas K, Adebiyi E, König R.
