Screening of mutations affecting protein stability and dynamics of FGFR1-A simulation analysis.

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Single amino acid substitutions in Fibroblast Growth Factor Receptor 1 (FGFR1) destabilize protein and have been implicated in several genetic disorders like various forms of cancer, Kallamann syndrome, Pfeiffer syndrome, Jackson Weiss syndrome, etc. In order to gain functional insight into mutation caused by amino acid substitution to protein function and expression, special emphasis was laid...

Published at Applied and Translational Genomics, 1, 37–43

Published in 2012

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Doss, C.G.P., Rajith, B., Garwasis, N., Mathew, P.R., Raju, A.S., Aproova, K., William, D., Sadhana, N.R., Himani, T., Dike, I.P.

Clement-Akomolafe Ijeoma » Mrs. Clement-Akomolafe is an expatriate faculty – Lecturer II in the Applied Biology & Biotechnology Programme of the Department of Biological Sciences. She is currently on her Ph.D. research work which focuses on the screening of indigenous anti-malarial plants for possible bio-active compounds that could lead to newer and more efficient drugs for malarial treatment. Her research... view full profile